Names & Taxonomy

Uniprot ID:
Q86VW1
Entry Name:
S22AG_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)
Gene Names:
SLC22A16 OCT6
Gene Names Primary:
SLC22A16
Organism:
Homo sapiens (Human)

Structure

Length:
577
Sequence:
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.
Cross Reference Drug Bank:
DB00997 DB00583
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
plasma membrane
amine transmembrane transporter activity
carnitine transmembrane transporter activity
organic cation transmembrane transporter activity
acid secretion
amine transport
carnitine transmembrane transport
carnitine transport
cell differentiation
multicellular organism development
organic cation transport
single fertilization
sperm motility
spermatogenesis
transmembrane transport
Gene Ontology Biological Process:
acid secretion
amine transport
carnitine transmembrane transport
carnitine transport
cell differentiation
multicellular organism development
organic cation transport
single fertilization
spermatogenesis
sperm motility
transmembrane transport
Gene Ontology Molecular Function:
amine transmembrane transporter activity
carnitine transmembrane transporter activity
organic cation transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Spermatogenesis
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12372408 12384147 12089149 15963465 14574404 15489334 14702039 17197897 17581421