Names & Taxonomy
- Uniprot ID:
- Q7L0J3
- Entry Name:
- SV2A_HUMAN
- Status:
- reviewed
- Protein Names:
- Synaptic vesicle glycoprotein 2A
- Gene Names:
- SV2A KIAA0736 PSEC0174
- Gene Names Orf:
- PSEC0174
- Gene Names Primary:
- SV2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 742
- Sequence:
- MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse
Function
- Function:
- Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
- Cross Reference Drug Bank:
- DB01202
- Gene Ontology Go:
- cell-cell junction
cytoplasm
endoplasmic reticulum
integral component of membrane
neuromuscular junction
plasma membrane
presynaptic active zone
synaptic vesicle
synaptic vesicle membrane
terminal bouton
protein kinase binding
receptor activity
transmembrane transporter activity
cellular calcium ion homeostasis
neurotransmitter transport - Gene Ontology Biological Process:
- cellular calcium ion homeostasis
neurotransmitter transport - Gene Ontology Molecular Function:
- protein kinase binding
receptor activity
transmembrane transporter activity - Gene Ontology Cellular Component:
- cell-cell junction
cytoplasm
endoplasmic reticulum
integral component of membrane
neuromuscular junction
plasma membrane
presynaptic active zone
synaptic vesicle
synaptic vesicle membrane
terminal bouton - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Complete proteome
Cytoplasmic vesicle
Glycoprotein
Membrane
Neurotransmitter transport
Phosphoprotein
Reference proteome
Synapse
Transmembrane
Transmembrane helix
Transport