Names & Taxonomy
- Uniprot ID:
- Q71U36
- Entry Name:
- TBA1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin alpha-1A chain (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain)
- Gene Names:
- TUBA1A TUBA3
- Gene Names Primary:
- TUBA1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 451
- Sequence:
- MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Cross Reference Drug Bank:
- DB00518 DB00643 DB00570
- Gene Ontology Go:
- cytoplasmic microtubule
cytoplasmic ribonucleoprotein granule
cytosol
extracellular exosome
microtubule
myelin sheath
nucleus
recycling endosome
GTP binding
GTPase activity
structural constituent of cytoskeleton
structural molecule activity
'de novo' posttranslational protein folding
cell division
cellular protein metabolic process
cytoskeleton-dependent intracellular transport
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
organelle organization
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cell division
cellular protein metabolic process
cytoskeleton-dependent intracellular transport
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
organelle organization
protein folding - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton
structural molecule activity - Gene Ontology Cellular Component:
- cytoplasmic microtubule
cytoplasmic ribonucleoprotein granule
cytosol
extracellular exosome
microtubule
myelin sheath
nucleus
recycling endosome - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Lissencephaly
Microtubule
Nitration
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q9NQC7; P00533; P05412