Names & Taxonomy

Uniprot ID:
Q6YBV0
Entry Name:
S36A4_HUMAN
Status:
reviewed
Protein Names:
Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4)
Gene Names:
SLC36A4 PAT4
Gene Names Primary:
SLC36A4
Organism:
Homo sapiens (Human)

Structure

Length:
504
Sequence:
MEAAATPAAAGAARREELDMDVMRPLINEQNFDGTSDEEHEQELLPVQKHYQLDDQEGISFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLGYSDTVSFAMEVSPWSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFISNSTNSSNPCERRSVDLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMKESKRFPQALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKEHYNIWMVLKNISIAFTGVVGFLLGTYITVEEIIYPTPKVVAGTPQSPFLNLNSTCLTSGLK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.1 uM for L-proline
Gene Ontology Go:
integral component of membrane
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity
L-tryptophan transmembrane transporter activity
symporter activity
L-alanine transport
proline transmembrane transport
proline transport
tryptophan transport
Gene Ontology Biological Process:
L-alanine transport
proline transmembrane transport
proline transport
tryptophan transport
Gene Ontology Molecular Function:
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity
L-tryptophan transmembrane transporter activity
symporter activity
Gene Ontology Cellular Component:
integral component of membrane
Keywords:
Acetylation
Alternative splicing
Amino-acid transport
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
14702039 15489334 21097500 22814378