Names & Taxonomy
- Uniprot ID:
- Q6UWV6
- Entry Name:
- ENPP7_HUMAN
- Status:
- reviewed
- Protein Names:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase)
- Gene Names:
- ENPP7 UNQ3077/PRO9912
- Gene Names Orf:
- UNQ3077/PRO9912
- Gene Names Primary:
- ENPP7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 458
- Sequence:
- MRGLAVLLTVALATLLAPGAGAPVQSQGSQNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTESALPPDGRPTLLPKGRSALPPSSRPLLVMGLLGTVILLSEVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
- Catalytic Activity:
- Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA.
- Active Site:
- ACT_SITE 75 75 Nucleophile.
- Gene Ontology Go:
- Golgi apparatus
integral component of membrane
membrane
microvillus
plasma membrane
sphingomyelin phosphodiesterase activity
glycosphingolipid metabolic process
negative regulation of cell proliferation
negative regulation of DNA replication
small molecule metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process
sphingomyelin metabolic process - Gene Ontology Biological Process:
- glycosphingolipid metabolic process
negative regulation of cell proliferation
negative regulation of DNA replication
small molecule metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process
sphingomyelin metabolic process - Gene Ontology Molecular Function:
- sphingomyelin phosphodiesterase activity
- Gene Ontology Cellular Component:
- Golgi apparatus
integral component of membrane
membrane
microvillus
plasma membrane - Keywords:
- Complete proteome
Direct protein sequencing
Glycoprotein
Hydrolase
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix