Names & Taxonomy

Uniprot ID:
Q6UWN8
Entry Name:
ISK6_HUMAN
Status:
reviewed
Protein Names:
Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor)
Gene Names:
SPINK6 UNQ844/PRO1782
Gene Names Orf:
UNQ844/PRO1782
Gene Names Primary:
SPINK6
Organism:
Homo sapiens (Human)

Structure

Length:
80
Sequence:
MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
Gene Ontology Go:
extracellular region
serine-type endopeptidase inhibitor activity
negative regulation of serine-type endopeptidase activity
Gene Ontology Biological Process:
negative regulation of serine-type endopeptidase activity
Gene Ontology Molecular Function:
serine-type endopeptidase inhibitor activity
Gene Ontology Cellular Component:
extracellular region
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Polymorphism
Protease inhibitor
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Serine protease inhibitor
Signal

Publication

PubMed ID:
20667819 12975309 15489334 15340161 21439340