Names & Taxonomy
- Uniprot ID:
- Q6UWN8
- Entry Name:
- ISK6_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor)
- Gene Names:
- SPINK6 UNQ844/PRO1782
- Gene Names Orf:
- UNQ844/PRO1782
- Gene Names Primary:
- SPINK6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 80
- Sequence:
- MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
- Gene Ontology Go:
- extracellular region
serine-type endopeptidase inhibitor activity
negative regulation of serine-type endopeptidase activity - Gene Ontology Biological Process:
- negative regulation of serine-type endopeptidase activity
- Gene Ontology Molecular Function:
- serine-type endopeptidase inhibitor activity
- Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Polymorphism
Protease inhibitor
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Serine protease inhibitor
Signal