Names & Taxonomy

Uniprot ID:
Q6PHW0
Entry Name:
IYD1_HUMAN
Status:
reviewed
Protein Names:
Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
Gene Names:
IYD C6orf71 DEHAL1
Gene Names Primary:
IYD
Organism:
Homo sapiens (Human)

Structure

Length:
289
Sequence:
MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
Catalytic Activity:
L-tyrosine + 2 NADP(+) + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.
Cofactor:
COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.67 uM for L-DIT
Gene Ontology Go:
integral component of membrane
plasma membrane
iodide peroxidase activity
oxidoreductase activity
cellular nitrogen compound metabolic process
small molecule metabolic process
thyroid hormone generation
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
small molecule metabolic process
thyroid hormone generation
Gene Ontology Molecular Function:
iodide peroxidase activity
oxidoreductase activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Congenital hypothyroidism
Disease mutation
FMN
Flavoprotein
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q86WT6

Publication

PubMed ID:
14574404 15489334 14702039 15289438 24275569 18434651