Names & Taxonomy
- Uniprot ID:
- Q6PHW0
- Entry Name:
- IYD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
- Gene Names:
- IYD C6orf71 DEHAL1
- Gene Names Primary:
- IYD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 289
- Sequence:
- MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
- Catalytic Activity:
- L-tyrosine + 2 NADP(+) + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.
- Cofactor:
- COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.67 uM for L-DIT
- Gene Ontology Go:
- integral component of membrane
plasma membrane
iodide peroxidase activity
oxidoreductase activity
cellular nitrogen compound metabolic process
small molecule metabolic process
thyroid hormone generation - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
small molecule metabolic process
thyroid hormone generation - Gene Ontology Molecular Function:
- iodide peroxidase activity
oxidoreductase activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Congenital hypothyroidism
Disease mutation
FMN
Flavoprotein
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q86WT6