Names & Taxonomy
- Uniprot ID:
- Q6P4A8
- Entry Name:
- PLBL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) [Cleaved into: Phospholipase B-like 1 chain A; Phospholipase B-like 1 chain B; Phospholipase B-like 1 chain C]
- Gene Names:
- PLBD1
- Gene Names Primary:
- PLBD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 553
- Sequence:
- MTRGGPGGRPGLPQPPPLLLLLLLLPLLLVTAEPPKPAGVYYATAYWMPAEKTVQVKNVMDKNGDAYGFYNNSVKTTGWGILEIRAGYGSQTLSNEIIMFVAGFLEGYLTAPHMNDHYTNLYPQLITKPSIMDKVQDFMEKQDKWTRKNIKEYKTDSFWRHTGYVMAQIDGLYVGAKKRAILEGTKPMTLFQIQFLNSVGDLLDLIPSLSPTKNGSLKVFKRWDMGHCSALIKVLPGFENILFAHSSWYTYAAMLRIYKHWDFNVIDKDTSSSRLSFSSYPGFLESLDDFYILSSGLILLQTTNSVFNKTLLKQVIPETLLSWQRVRVANMMADSGKRWADIFSKYNSGTYNNQYMVLDLKKVKLNHSLDKGTLYIVEQIPTYVEYSEQTDVLRKGYWPSYNVPFHEKIYNWSGYPLLVQKLGLDYSYDLAPRAKIFRRDQGKVTDTASMKYIMRYNNYKKDPYSRGDPCNTICCREDLNSPNPSPGGCYDTKVADIYLASQYTSYAISGPTVQGGLPVFRWDRFNKTLHQGMPEVYNFDFITMKPILKLDIK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome
Function
- Function:
- In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.
- Gene Ontology Go:
- cytosol
extracellular space
lysosome
hydrolase activity
glycerophospholipid biosynthetic process
lipid catabolic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
lipid catabolic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- hydrolase activity
- Gene Ontology Cellular Component:
- cytosol
extracellular space
lysosome - Keywords:
- Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Lysosome
Polymorphism
Reference proteome
Signal