Names & Taxonomy
- Uniprot ID:
- Q6NS38
- Entry Name:
- ALKB2_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1)
- Gene Names:
- ALKBH2 ABH2
- Gene Names Primary:
- ALKBH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Catalytic Activity:
- DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by ascorbate and magnesium ions.
- Cross Reference Drug Bank:
- DB00126
- Gene Ontology Go:
- microtubule cytoskeleton
nucleoplasm
nucleus
cytosine C-5 DNA demethylase activity
DNA-N1-methyladenine dioxygenase activity
ferrous iron binding
DNA dealkylation involved in DNA repair
DNA demethylation
DNA repair
oxidative demethylation
oxidative DNA demethylation - Gene Ontology Biological Process:
- DNA dealkylation involved in DNA repair
DNA demethylation
DNA repair
oxidative demethylation
oxidative DNA demethylation - Gene Ontology Molecular Function:
- cytosine C-5 DNA demethylase activity
DNA-N1-methyladenine dioxygenase activity
ferrous iron binding - Gene Ontology Cellular Component:
- microtubule cytoskeleton
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
DNA damage
DNA repair
Dioxygenase
Iron
Magnesium
Metal-binding
Nucleus
Oxidoreductase
Polymorphism
Reference proteome