Names & Taxonomy

Uniprot ID:
Q6JEL2
Entry Name:
KLH10_HUMAN
Status:
reviewed
Protein Names:
Kelch-like protein 10
Gene Names:
KLHL10
Gene Names Primary:
KLHL10
Organism:
Homo sapiens (Human)

Structure

Length:
608
Sequence:
MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.
Pathway:
Protein modification; protein ubiquitination.
Gene Ontology Go:
Cul3-RING ubiquitin ligase complex
cytoplasm
cell morphogenesis
fertilization
homeostasis of number of cells within a tissue
male genitalia morphogenesis
male gonad development
protein ubiquitination
spermatid development
Gene Ontology Biological Process:
cell morphogenesis
fertilization
homeostasis of number of cells within a tissue
male genitalia morphogenesis
male gonad development
protein ubiquitination
spermatid development
Gene Ontology Cellular Component:
Cul3-RING ubiquitin ligase complex
cytoplasm
Keywords:
Complete proteome
Cytoplasm
Differentiation
Disease mutation
Kelch repeat
Phosphoprotein
Reference proteome
Repeat
Spermatogenesis
Ubl conjugation pathway

Publication

PubMed ID:
15136734 14702039 17047026