Names & Taxonomy
- Uniprot ID:
- Q66K79
- Entry Name:
- CBPZ_HUMAN
- Status:
- reviewed
- Protein Names:
- Carboxypeptidase Z (CPZ) (EC 3.4.17.-)
- Gene Names:
- CPZ
- Gene Names Primary:
- CPZ
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 652
- Sequence:
- MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2 mM for dansyl-Phe-Ala-Arg
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA.
- Active Site:
- ACT_SITE 472 472 Proton donor/acceptor.
- Gene Ontology Go:
- extracellular exosome
extracellular space
proteinaceous extracellular matrix
metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding
peptide metabolic process
protein processing
proteolysis
Wnt signaling pathway - Gene Ontology Biological Process:
- peptide metabolic process
protein processing
proteolysis
Wnt signaling pathway - Gene Ontology Molecular Function:
- metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular space
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Carboxypeptidase
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Wnt signaling pathway
Zinc