Names & Taxonomy
- Uniprot ID:
- Q59GA2
- Entry Name:
- Q59GA2_HUMAN
- Status:
- unreviewed
- Protein Names:
- Thyrotropin receptor (Fragment)
- Gene Names:
- TSHR
- Gene Names Primary:
- TSHR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 770
- Sequence:
- PRVPWKMRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
- Gene Ontology Go:
- integral component of membrane
plasma membrane
thyroid-stimulating hormone receptor activity - Gene Ontology Molecular Function:
- thyroid-stimulating hormone receptor activity
- Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Cell membrane
G-protein coupled receptor
Leucine-rich repeat
Membrane
Receptor
Repeat
Signal
Transducer
Transmembrane
Transmembrane helix