Names & Taxonomy

Uniprot ID:
Q59FI0
Entry Name:
Q59FI0_HUMAN
Status:
unreviewed
Protein Names:
Aconitate hydratase (Aconitase) (EC 4.2.1.3) (Fragment)
Organism:
Homo sapiens (Human)

Structure

Length:
781
Sequence:
QLEPRSARERVPLLGSGSPVAGAPPCSRRNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGFERQLTQENTDLCLSPPLLTSLSSPLKLWGQLFCHGEQCLGDLEK

Function

Function:
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Catalytic Activity:
Citrate = isocitrate.
Cofactor:
COFACTOR: ; Note=Binds 1 cluster per subunit.
Gene Ontology Go:
cell
4 iron, 4 sulfur cluster binding
aconitate hydratase activity
cellular iron ion homeostasis
response to iron(II) ion
Gene Ontology Biological Process:
cellular iron ion homeostasis
response to iron(II) ion
Gene Ontology Molecular Function:
4 iron, 4 sulfur cluster binding
aconitate hydratase activity
Gene Ontology Cellular Component:
cell
Keywords:
4Fe-4S
Iron
Iron-sulfur
Lyase
Metal-binding