Names & Taxonomy

Uniprot ID:
Q53XZ3
Entry Name:
Q53XZ3_HUMAN
Status:
unreviewed
Protein Names:
Muscarinic acetylcholine receptor
Gene Names:
CHRM1 hCG_2020133
Gene Names Orf:
hCG_2020133
Gene Names Primary:
CHRM1
Organism:
Homo sapiens (Human)

Structure

Length:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Gene Ontology Go:
asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
postsynaptic density
postsynaptic membrane
drug binding
G-protein coupled acetylcholine receptor activity
cognition
neuromuscular synaptic transmission
positive regulation of intracellular protein transport
regulation of locomotion
saliva secretion
Gene Ontology Biological Process:
cognition
neuromuscular synaptic transmission
positive regulation of intracellular protein transport
regulation of locomotion
saliva secretion
Gene Ontology Molecular Function:
drug binding
G-protein coupled acetylcholine receptor activity
Gene Ontology Cellular Component:
asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
postsynaptic density
postsynaptic membrane
Keywords:
Cell junction
Cell membrane
G-protein coupled receptor
Membrane
Postsynaptic cell membrane
Receptor
Synapse
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995