Names & Taxonomy
- Uniprot ID:
- Q53X12
- Entry Name:
- Q53X12_HUMAN
- Status:
- unreviewed
- Protein Names:
- V-type proton ATPase subunit a
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 831
- Sequence:
- MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAHVSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEHIREGKFEE
Function
- Function:
- Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
- Gene Ontology Go:
- integral component of membrane
vacuolar proton-transporting V-type ATPase, V0 domain
hydrogen ion transmembrane transporter activity
ATP hydrolysis coupled proton transport - Gene Ontology Biological Process:
- ATP hydrolysis coupled proton transport
- Gene Ontology Molecular Function:
- hydrogen ion transmembrane transporter activity
- Gene Ontology Cellular Component:
- integral component of membrane
vacuolar proton-transporting V-type ATPase, V0 domain - Keywords:
- Coiled coil
Hydrogen ion transport
Ion transport
Membrane
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P06927