Names & Taxonomy

Uniprot ID:
Q4G0N8
Entry Name:
SL9C1_HUMAN
Status:
reviewed
Protein Names:
Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE)
Gene Names:
SLC9C1 SLC9A10
Gene Names Primary:
SLC9C1
Organism:
Homo sapiens (Human)

Structure

Length:
1177
Sequence:
MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSVISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFSWRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILPVAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENPYMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGINKLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEEGDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell projection, cilium, flagellum membrane

Function

Function:
Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).
Gene Ontology Go:
integral component of membrane
motile cilium
plasma membrane
solute:proton antiporter activity
cell differentiation
ion transmembrane transport
multicellular organism development
sodium ion transport
sperm motility
spermatogenesis
transmembrane transport
Gene Ontology Biological Process:
cell differentiation
ion transmembrane transport
multicellular organism development
sodium ion transport
spermatogenesis
sperm motility
transmembrane transport
Gene Ontology Molecular Function:
solute:proton antiporter activity
Gene Ontology Cellular Component:
integral component of membrane
motile cilium
plasma membrane
Keywords:
Alternative splicing
Antiport
Cell membrane
Cell projection
Cilium
Complete proteome
Developmental protein
Differentiation
Flagellum
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Spermatogenesis
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
14702039 15489334 12783626