Names & Taxonomy
- Uniprot ID:
- Q4G0N8
- Entry Name:
- SL9C1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE)
- Gene Names:
- SLC9C1 SLC9A10
- Gene Names Primary:
- SLC9C1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1177
- Sequence:
- MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSVISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFSWRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILPVAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENPYMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGINKLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEEGDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell projection, cilium, flagellum membrane
Function
- Function:
- Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).
- Gene Ontology Go:
- integral component of membrane
motile cilium
plasma membrane
solute:proton antiporter activity
cell differentiation
ion transmembrane transport
multicellular organism development
sodium ion transport
sperm motility
spermatogenesis
transmembrane transport - Gene Ontology Biological Process:
- cell differentiation
ion transmembrane transport
multicellular organism development
sodium ion transport
spermatogenesis
sperm motility
transmembrane transport - Gene Ontology Molecular Function:
- solute:proton antiporter activity
- Gene Ontology Cellular Component:
- integral component of membrane
motile cilium
plasma membrane - Keywords:
- Alternative splicing
Antiport
Cell membrane
Cell projection
Cilium
Complete proteome
Developmental protein
Differentiation
Flagellum
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Spermatogenesis
Transmembrane
Transmembrane helix
Transport