Names & Taxonomy
- Uniprot ID:
- P49862
- Entry Name:
- KLK7_HUMAN
- Status:
- reviewed
- Protein Names:
- Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)
- Gene Names:
- KLK7 PRSS6 SCCE
- Gene Names Primary:
- KLK7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 253
- Sequence:
- MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
- Catalytic Activity:
- Cleavage of proteins with aromatic side chains in the P1 position.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12.
- Active Site:
- ACT_SITE 70 70 Charge relay system.
- Gene Ontology Go:
- epidermal lamellar body
extracellular region
extracellular space
peptidase activity
serine-type endopeptidase activity
serine-type peptidase activity
epidermis development
extracellular matrix disassembly
extracellular matrix organization
positive regulation of antibacterial peptide production - Gene Ontology Biological Process:
- epidermis development
extracellular matrix disassembly
extracellular matrix organization
positive regulation of antibacterial peptide production - Gene Ontology Molecular Function:
- peptidase activity
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- epidermal lamellar body
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen