Names & Taxonomy

Uniprot ID:
P19174
Entry Name:
PLCG1_HUMAN
Status:
reviewed
Protein Names:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene Names:
PLCG1 PLC1
Gene Names Primary:
PLCG1
Organism:
Homo sapiens (Human)

Structure

Length:
1290
Sequence:
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

Function

Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Catalytic Activity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Enzyme Regulation:
ENZYME REGULATION: Activated by phosphorylation on tyrosine residues.
Active Site:
ACT_SITE 335 335
Gene Ontology Go:
cell projection
cell-cell junction
COP9 signalosome
cytoplasm
cytosol
lamellipodium
plasma membrane
ruffle
calcium ion binding
neurotrophin TRKA receptor binding
phosphatidylinositol phospholipase C activity
phospholipase C activity
protein kinase binding
receptor signaling protein activity
activation of MAPKK activity
activation of phospholipase C activity
axon guidance
blood coagulation
calcium-mediated signaling
cell migration
cellular response to epidermal growth factor stimulus
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
in utero embryonic development
innate immune response
inositol phosphate metabolic process
leukocyte migration
neurotrophin TRK receptor signaling pathway
phospholipid catabolic process
positive regulation of angiogenesis
positive regulation of blood vessel endothelial cell migration
positive regulation of epithelial cell migration
positive regulation of release of sequestered calcium ion into cytosol
signal transduction
small molecule metabolic process
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Biological Process:
activation of MAPKK activity
activation of phospholipase C activity
axon guidance
blood coagulation
calcium-mediated signaling
cell migration
cellular response to epidermal growth factor stimulus
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
inositol phosphate metabolic process
in utero embryonic development
leukocyte migration
neurotrophin TRK receptor signaling pathway
phospholipid catabolic process
positive regulation of angiogenesis
positive regulation of blood vessel endothelial cell migration
positive regulation of epithelial cell migration
positive regulation of release of sequestered calcium ion into cytosol
signal transduction
small molecule metabolic process
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Molecular Function:
calcium ion binding
neurotrophin TRKA receptor binding
phosphatidylinositol phospholipase C activity
phospholipase C activity
protein kinase binding
receptor signaling protein activity
Gene Ontology Cellular Component:
cell-cell junction
cell projection
COP9 signalosome
cytoplasm
cytosol
lamellipodium
plasma membrane
ruffle
Keywords:
3D-structure
Acetylation
Alternative splicing
Calcium
Cell projection
Complete proteome
Host-virus interaction
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH2 domain
SH3 domain
Transducer
Ubl conjugation
Interacts With:
P42684; P31749; P10275; Q9ULH1; O43150; P20273; Q9BZW8; Q9H1R2; Q71V39; P00533; P04626; P21860; P31994; P11362; P17948; Q13480; P62993; P08631; P06213; Q07666; P10721; O43561; Q13094; Q92918; P08581; P09619; P63000; P07949; Q8TB24; Q14108; O14796; Q9UPX8; Q9BYB0; Q15036; Q07889; Q07890; P43405; P09327

Publication

PubMed ID:
2167438 11780052 15489334 1656221 1370476 7518429 8657103 9038210 9178760 9489702 10488157 10102632 10873601 11518702 10747847 11259588 11564877 12913111 15144186 15488758 15526160 15270728 15102829 15215251 16081816 16844695 17229814 17561467 17620338 18669648 19413330 19286672 19690332 20494825 20068231 21269460 21765395 21406692 22561606 15863030 7681365