Names & Taxonomy

Uniprot ID:
P16444
Entry Name:
DPEP1_HUMAN
Status:
reviewed
Protein Names:
Dipeptidase 1 (EC 3.4.13.19) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)
Gene Names:
DPEP1 MDP RDP
Gene Names Primary:
DPEP1
Organism:
Homo sapiens (Human)

Structure

Length:
411
Sequence:
MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLASLAPLVLCLSLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane.

Function

Function:
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.
Catalytic Activity:
Hydrolysis of dipeptides.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by L-penicillamine.
Cross Reference Drug Bank:
DB01597 DB06211
Gene Ontology Go:
anchored component of membrane
apical part of cell
apical plasma membrane
extracellular exosome
extracellular space
microvillus membrane
plasma membrane
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
dipeptidyl-peptidase activity
GPI anchor binding
metallodipeptidase activity
metalloexopeptidase activity
modified amino acid binding
zinc ion binding
antibiotic metabolic process
arachidonic acid metabolic process
cellular lactam catabolic process
cellular response to calcium ion
cellular response to drug
cellular response to nitric oxide
glutathione metabolic process
homocysteine metabolic process
leukotriene metabolic process
negative regulation of apoptotic process
negative regulation of cell migration
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
antibiotic metabolic process
arachidonic acid metabolic process
cellular lactam catabolic process
cellular response to calcium ion
cellular response to drug
cellular response to nitric oxide
glutathione metabolic process
homocysteine metabolic process
leukotriene metabolic process
negative regulation of apoptotic process
negative regulation of cell migration
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
dipeptidyl-peptidase activity
GPI anchor binding
metallodipeptidase activity
metalloexopeptidase activity
modified amino acid binding
zinc ion binding
Gene Ontology Cellular Component:
anchored component of membrane
apical part of cell
apical plasma membrane
extracellular exosome
extracellular space
microvillus membrane
plasma membrane
Keywords:
3D-structure
Cell membrane
Cell projection
Complete proteome
Dipeptidase
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Signal
Zinc
Interacts With:
Q92624; Q96EK5

Publication

PubMed ID:
8439558 2303490 7764673 15489334 2137335 2768222 15340161 2168407 8097406 19159218 12144777 16959974