Names & Taxonomy
- Uniprot ID:
- P16444
- Entry Name:
- DPEP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Dipeptidase 1 (EC 3.4.13.19) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)
- Gene Names:
- DPEP1 MDP RDP
- Gene Names Primary:
- DPEP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 411
- Sequence:
- MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLASLAPLVLCLSLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane.
Function
- Function:
- Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.
- Catalytic Activity:
- Hydrolysis of dipeptides.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by L-penicillamine.
- Cross Reference Drug Bank:
- DB01597 DB06211
- Gene Ontology Go:
- anchored component of membrane
apical part of cell
apical plasma membrane
extracellular exosome
extracellular space
microvillus membrane
plasma membrane
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
dipeptidyl-peptidase activity
GPI anchor binding
metallodipeptidase activity
metalloexopeptidase activity
modified amino acid binding
zinc ion binding
antibiotic metabolic process
arachidonic acid metabolic process
cellular lactam catabolic process
cellular response to calcium ion
cellular response to drug
cellular response to nitric oxide
glutathione metabolic process
homocysteine metabolic process
leukotriene metabolic process
negative regulation of apoptotic process
negative regulation of cell migration
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- antibiotic metabolic process
arachidonic acid metabolic process
cellular lactam catabolic process
cellular response to calcium ion
cellular response to drug
cellular response to nitric oxide
glutathione metabolic process
homocysteine metabolic process
leukotriene metabolic process
negative regulation of apoptotic process
negative regulation of cell migration
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
dipeptidyl-peptidase activity
GPI anchor binding
metallodipeptidase activity
metalloexopeptidase activity
modified amino acid binding
zinc ion binding - Gene Ontology Cellular Component:
- anchored component of membrane
apical part of cell
apical plasma membrane
extracellular exosome
extracellular space
microvillus membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Cell projection
Complete proteome
Dipeptidase
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Signal
Zinc - Interacts With:
- Q92624; Q96EK5