Names & Taxonomy
- Uniprot ID:
- P11473
- Entry Name:
- VDR_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
- Gene Names:
- VDR NR1I1
- Gene Names Primary:
- VDR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 427
- Sequence:
- MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
- Cross Reference Drug Bank:
- DB01436 DB00146 DB02300 DB00136 DB00169 DB01070 DB00153 DB00910
- Gene Ontology Go:
- nucleoplasm
nucleus
receptor complex
RNA polymerase II transcription factor complex
calcitriol binding
calcitriol receptor activity
DNA binding
lithocholic acid binding
lithocholic acid receptor activity
retinoid X receptor binding
sequence-specific DNA binding
steroid hormone receptor activity
zinc ion binding
bile acid signaling pathway
calcium ion transport
cell morphogenesis
cellular calcium ion homeostasis
decidualization
gene expression
intestinal absorption
lactation
mammary gland branching involved in pregnancy
negative regulation of cell proliferation
negative regulation of keratinocyte proliferation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of apoptotic process involved in mammary gland involution
positive regulation of gene expression
positive regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vitamin D 24-hydroxylase activity
regulation of calcidiol 1-monooxygenase activity
signal transduction
skeletal system development
transcription initiation from RNA polymerase II promoter
vitamin D receptor signaling pathway - Gene Ontology Biological Process:
- bile acid signaling pathway
calcium ion transport
cell morphogenesis
cellular calcium ion homeostasis
decidualization
gene expression
intestinal absorption
lactation
mammary gland branching involved in pregnancy
negative regulation of cell proliferation
negative regulation of keratinocyte proliferation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
positive regulation of apoptotic process involved in mammary gland involution
positive regulation of gene expression
positive regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vitamin D 24-hydroxylase activity
regulation of calcidiol 1-monooxygenase activity
signal transduction
skeletal system development
transcription initiation from RNA polymerase II promoter
vitamin D receptor signaling pathway - Gene Ontology Molecular Function:
- calcitriol binding
calcitriol receptor activity
DNA binding
lithocholic acid binding
lithocholic acid receptor activity
retinoid X receptor binding
sequence-specific DNA binding
steroid hormone receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- nucleoplasm
nucleus
receptor complex
RNA polymerase II transcription factor complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
DNA-binding
Disease mutation
Metal-binding
Nucleus
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger - Interacts With:
- Q09472; Q9JLI4; P26045; Q13573; P04637