Names & Taxonomy
- Uniprot ID:
- P00450
- Entry Name:
- CERU_HUMAN
- Status:
- reviewed
- Protein Names:
- Ceruloplasmin (EC 1.16.3.1) (Ferroxidase)
- Gene Names:
- CP
- Gene Names Primary:
- CP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1065
- Sequence:
- MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments.
Function
- Function:
- Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
- Catalytic Activity:
- 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.
- Cofactor:
- COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; ; Note=Binds 6 Cu cations per monomer.;
- Cross Reference Drug Bank:
- DB00055
- Gene Ontology Go:
- anchored component of plasma membrane
blood microparticle
extracellular exosome
extracellular region
extracellular space
lysosomal membrane
chaperone binding
copper ion binding
ferroxidase activity
aging
cellular iron ion homeostasis
copper ion transport
liver development
lung development
response to copper ion
response to nutrient
transmembrane transport - Gene Ontology Biological Process:
- aging
cellular iron ion homeostasis
copper ion transport
liver development
lung development
response to copper ion
response to nutrient
transmembrane transport - Gene Ontology Molecular Function:
- chaperone binding
copper ion binding
ferroxidase activity - Gene Ontology Cellular Component:
- anchored component of plasma membrane
blood microparticle
extracellular exosome
extracellular region
extracellular space
lysosomal membrane - Keywords:
- 3D-structure
Complete proteome
Copper
Copper transport
Direct protein sequencing
Disulfide bond
Glycoprotein
Ion transport
Metal-binding
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transport