Names & Taxonomy
- Uniprot ID:
- A0A024R5C5
- Entry Name:
- A0A024R5C5_HUMAN
- Status:
- unreviewed
- Protein Names:
- Pyruvate carboxylase (EC 6.4.1.1)
- Gene Names:
- PC hCG_20121
- Gene Names Orf:
- hCG_20121
- Gene Names Primary:
- PC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1178
- Sequence:
- MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE
Function
- Function:
- Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
- Catalytic Activity:
- ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.
- Cofactor:
- COFACTOR: Name=biotin; Xref=ChEBI:CHEBI:57586;
- Active Site:
- ACT_SITE 328 328
- Gene Ontology Go:
- mitochondrion
ATP binding
biotin binding
biotin carboxylase activity
DNA binding
metal ion binding
pyruvate carboxylase activity
gluconeogenesis
oxaloacetate metabolic process
pyruvate metabolic process - Gene Ontology Biological Process:
- gluconeogenesis
oxaloacetate metabolic process
pyruvate metabolic process - Gene Ontology Molecular Function:
- ATP binding
biotin binding
biotin carboxylase activity
DNA binding
metal ion binding
pyruvate carboxylase activity - Gene Ontology Cellular Component:
- mitochondrion
- Keywords:
- ATP-binding
Biotin
Ligase
Metal-binding
Nucleotide-binding
Pyruvate
Publication
- PubMed ID:
- 11181995